Cannabis Impairment Detection Application (CIDA)

Inclusion Criteria: * Men and women 18 to 50 years of age in good health (21 to 50 for alcohol arm) * Valid US driver's license and have been licensed driver for two years * Restrictions on driver's license limited to vision correction only * Drive at least three times per week * Must be able to drive without special or non-standard equipment * Must be able to attend three morning daytime study visits lasting approximately 5 to 6 hours * Must be willing to abstain from alcohol use in the day prior to their study appointments * Must be willing to abstain from use of their own cannabis while enrolled in the study * Live within 1-hour driving radius of National Advanced Driving Simulator (NADS) * Must currently use cannabis at least once every three months and no more than four times per week (must be current user) * Peripheral veins suitable for venipuncture * Blood pressure within clinically normal range * If invited to complete alcohol arm: Must be considered a light or moderate drinker according to Quantity-Frequency-Variability Scale (QFV) or, if a heavy drinker, not drink more than 1-2 times a week and not have a modal quantity of 5-6 drinks Exclusion Criteria: * Females who are pregnant or test positive for pregnancy or are breastfeeding * Any known sleep disorders, or family history of sleep disorders * Any neurological or pulmonary disorders (or taking medications for such) * Any psychiatric disorder (or taking medications for such) * Any eating disorders * Recent (past 5 years) head injury, or older head injury with current symptoms * High blood pressure, Heart disease, diabetes, or history of stroke or taking medications to treat * Any known behavioral or attention disorder (or taking medications for such) * Untreated/Untreatable vision or auditory issues (because testing currently requires both senses) * Excessive tobacco use (more than 10 cigarettes a day) * Excessive caffeine use (5 or more servings per day) * Excessive alcohol (20 or more drinks per week) * Donation of 450 mL or more of blood in the two weeks preceding study drug administration * Regular use of pain medications other than over-the-counter * Any medication use that causes drowsiness or is contraindicated for driving * Use of prescription drugs not prescribed to them or illicit drugs other than cannabis * Propensity to motion sickness (more than 2-3 episodes where intensity is moderate or above) * History of substance abuse or substance addiction * Currently participating in or interested in drug abuse treatment, or participation in a program in past 60 days * Current cannabis use disorder or alcohol use disorder \[as determined by scores on the Cannabis Use Disorder Identification Test (CUDIT) and Alcohol Use Disorder Identification Test (AUDIT)\]