Trial of ERapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance

Inclusion Criteria: 1. Sign and date an informed consent form. 2. Stated willingness to comply with all study procedures and availability for the duration of the study. 3. Male or female, age at least 18 years at the time of consent. 4. Phenotypic familial adenomatous polyposis (FAP) with disease involvement of the colorectum by either genetic or clinical diagnosis: Adenomatous polyposis coli (APC) germline mutation with or without family history, or with greater than a cumulative lifetime history of (\>) 100 adenomas in large intestine and a family history of FAP, or FAP phenotype post colectomy for polyposis with a family history of FAP. Minimum number of polyps required for enrollment is 10. 5. Abilitiy to safely undergo endoscopy. 6. Ability to take oral medication and be willing to adhere to the eRapa regimen. 7. For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation and for an additional 12 weeks after the end of eRapa administration. 8. A woman must agree not to breast feed or donate eggs (ova, oocytes) during the study and for a period of 12 weeks after the last administration of study drug. Exclusion Criteria: 1. Risk-reduction surgery (colectomy or partial colectomy) within the 12 months prior to screening. 2. Use of non-steroidal anti-inflammatory drugs other than aspirin during the study. The use of 81 milligrams (mg) of aspirin a day or 650 mg of aspirin per week is allowed. 3. Treatment with other FAP-directed drug therapy (including NSAID \[Non-steroidal anti-inflammatory drug\] drugs), unless completes a 4 week washout period prior to enrollment. 4. Duodenum or colon/ rectum with high grade dysplasia or cancer on biopsy at screening. 5. Duodenal or colorectal polyp \> 1 centimeter (cm) not excised at the screening evaluation. 6. Pregnancy or breast feeding. 7. Unable to provide consent or anticipated inability to attend appropriate follow-up visits. 8. Serum creatinine or measured/ calculated creatinine clearance (or glomerular filtration rate \[GFR\]) \> 1.5 x ULN OR \< 30mL/min for participants with creatine levels \> 1.5 x institutional ULN. Bilirubin ≥ 1.5 x ULN unless conjugated bilirubin ≤ ULN; alkaline phosphatase \> 5 x ULN; ALT/AST \> 2 x ULN. 9. INR or PT or aPTT \> 1.5 x institutional ULN unless the patient is receiving anticoagulant therapy as long as the PT or aPTT is within therapeutic range of intended use of anticoagulants. 10. Proteinuria \> 1+ on urinalysis or \> 1g/24h on 24h urine. 11. History of interstitial lung disease or non-infectious pneumonitis. 12. Immunosuppressed state (e.g., HIV, use of chronic steroids), active, uncontrolled infection. 13. On agents known to alter rapamycin metabolism significantly. 14. Concurrent involvement in other clinical trials specifically evaluating chemoprevention in FAP. 15. Patients with a colonic polyp burden too numerous to count.