The purpose of this study is to determine if NT-BNP levels obtained at time of admission for delivery are predictive of intrapartum or postpartum complications in patients with adult congenital heart disease.
Amino-terminal pro-B-type natiuretic peptide (NT-proBNP) is a prohormone released from cardiac ventricular myocytes in direct response to cardiac workload. Secreted in the biologically inactive form, NT-proBNP is cleaved in the circulation into BNP, which subsequently exerts both vasodilatory and diuretic effects. The principal clinical utility of serum NT-proBNP measurement has been as an adjunctive marker in the diagnosis of subclinical heart failure, with higher levels typically reflective of increasing cardiac dysfunction. The proposed prospective cohort study intends to collect serum NT-proBNP levels in singleton ACHD patients and a comparative normotensive control group at time of admission for delivery to characterize negative predictive values for intrapartum and postpartum cardiac events. Both pregnant patients with previously-diagnosed ACHD and those diagnosed and delivering during the study interval will be candidates for participation, and a gestational age threshold of 37 weeks will be utilized for the control group.
Study Type
OBSERVATIONAL
Enrollment
34
Collect serum NT-proBNP levels in singleton ACHD patients and a comparative normotensive control group at time of admission for delivery to characterize negative predictive values for intrapartum and postpartum cardiac events.
Mayo Clinic
Rochester, Minnesota, United States
Intrapartum cardiac complications
Incidence of heart failure, incidence of arrhythmia, incidence of cardiac arrest
Time frame: Inpatient admission for subsequent 48 hours
Postpartum cardiac complications
Incidence of heart failure, incidence of arrhythmia, incidence of cardiac arrest
Time frame: Initial 96 hours following delivery of infant(s)
Intrapartum obstetrical complications
Incidence of preeclampsia or gestational hypertension, incidence of placental abruption, cesarean section rate
Time frame: Inpatient admission for subsequent 48 hours
Postpartum obstetrical complications
Incidence of postpartum hemorrhage, incidence of venous thromboembolism
Time frame: Initial 96 hours following delivery of infant(s)
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