To investigate the hemodynamic effects of CGRP after glibenclamide administration.
20 healthy participants will randomly be allocated to receive CGRP infusion followed by glibenclamide or placebo on two different days. The aim of the study is to investigate the vascular effect of CGRP after glibenclamide administration. Repeated measurements covering the arteria radialis (RA), superficiel temporal artery (STA) and middle cerebral artery (MCA) before and after glibenclamide/placebo administration and CGRP infusion.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
20
Oral administration of glibenclamide or placebo. To investigate the role of CGRP on cranial arteries in healthy volunteers after glibenclamide/placebo administration .
CGRP infusion
placebo
Danish headache center
Glostrup Municipality, Copenhagen, Denmark
Mohammad Al-Mahdi Al-Karagholi
København S, Danmark, Denmark
Changes in the arterial radialis (RA), superficiel temporal artery (STA) and middle cerebral artery (MCA)
Repeated measurements covering the diameter of RA , STA and MCA before and after glibenclamide/placebo administration and CGRP infusion measured by centimeter (cm)
Time frame: Time of measurements is baseline and repeatedly every 20 min for 240 min.
Headache
Headache intensity will be recorded by numerical rating scale (NRS) from 0 to 10 (0, no headache; 1, a feeling of pressure; 10, worst imaginable headache).
Time frame: Time of headache measurements is from before (-20 min) and after (12 hours) glibenclamide/placebo administration.
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