Ketogenic Diet in Patients With Untreated Low Tumor Burden Mantle Cell Lymphoma

Inclusion Criteria: * Histologically confirmed diagnosis of mantle cell lymphoma * Age ≥ 18 years * No prior systemic therapy for lymphoma * ECOG performance status ≤ 2 * Required initial laboratory parameters: * Absolute neutrophil count (ANC) ≥ 1000 cells/mm3 * Platelet count ≥ 75,000 cells/mm3 * Calculated creatinine clearance ≥ 30 ml/min by Cockcroft-Gault formula * Total bilirubin ≤ 2.0 x ULN * AST/SGOT or ALT/SGPT ≤ 3.0 x ULN * Understand and voluntarily sign an ICF prior to any study related assessments and procedures are conducted Exclusion Criteria: * Patients with blastoid histology * Patients with known or suspected central nervous system (CNS) involvement * Patients with a clear indication for treatment of lymphoma, including those with a tumor larger than 6 cm, more than 3 lymph nodes more than 3 cm, or constitutional symptoms * Active viral infection with HIV or hepatitis type B or C. Seropositive HBV patients are eligible if they are negative for HBV DNA by PCR and receive concomitant antiviral therapy during treatment and for additional six months after coming off study. * Active uncontrolled systemic fungal, bacterial or viral infection (defined as ongoing signs/symptoms related to the infection without improvement despite appropriate antibiotics, antiviral therapy and/or other treatment) * Uncontrolled moderate to severe hypertriglyceridemia (TG\>300 mg/dL). * Strong family history of hypertriglyceridemia and coronary artery disease. * Myocardial infarction within 6 months of cycle 1, day 1. \[Subjects with a history of myocardial infarction between 6 and 12 months prior to cycle 1, day 1, who are asymptomatic and have had a negative cardiac risk assessment (treadmill stress test, nuclear medicine stress test, or stress echocardiogram) since the event, may participate\]. * Symptomatic coronary artery disease (CAD), e.g., angina Canadian Class II-IV. In any patient in whom there is doubt, the patient should have a stress imaging study and, if abnormal, angiography to define whether or not CAD is present. * An ECG recorded at screening showing evidence of cardiac ischemia (ST depression of ≥ 2 mm, measured from isoelectric line to the ST segment). If in any doubt, the patient should have a stress imaging study and, if abnormal, angiography to define whether or not CAD is present. * Congestive heart failure (CHF) that meets New York Heart Association (NYHA) Class II to IV definitions and/or ejection fraction \< 40% by multigated acquisition (MUGA) scan or \< 50% by echocardiogram and/or magnetic resonance imaging (MRI). * Arterial or venous thrombotic or embolic events such as cerebrovascular accident (including transient ischemic attacks), deep vein thrombosis or pulmonary embolism within 3 months before the start of study medication. * Patients requiring dual anti-platelets treatment for cardiac conditions or patients who are on anticoagulation for arterial or venous thrombosis. * Patients with known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial. * Type I diabetes * Uncontrolled Type II diabetes mellitus (HbA1c\> 7.5%). * Type II diabetes requiring treatment with a sulfonylurea, meglitinide, or insulin. * Malabsorption syndrome, disease significantly affecting gastrointestinal function, or resection of the stomach or small bowel that is likely to affect absorption, symptomatic inflammatory bowel disease, partial or complete bowel obstruction, or gastric restrictions and bariatric surgery, such as gastric bypass. * Active complaints of dysphagia or odynophagia * Presence of a "feeding tube" (i.e. nasogastric tube, PEG, PEJ) * Participation in a specialty diet (e.g. Atkins, Weight Watchers, Best Life, Nutrisystem, South Beach, Jenny Craig, Paleo Diet, Zone, etc) or weight loss plan within 28 days prior to Cycle 1 of treatment. * Vegetarian or vegan eating habits. * An allergy or intolerance to egg, gluten, tree nuts, or milk protein. * History of serious or uncontrolled gout or hyperuricemia * Diagnosis of a seizure disorder. * Prior diagnosis of restless legs syndrome or a history of chronic muscle cramps, as defined as a period of at least 1 month where spontaneous cramping of the skeletal muscles occurred more than two-thirds of the days. * Patients who are pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the pre-screening or screening visit through at least 30 days after the last dose of trial treatment. * History of nephrolithiasis or nephrolithiasis incidentally discovered during CT screening. * Known selenium deficiency.