Olanzapine for Chemotherapy-induced Nausea and Vomiting Prophylaxis

Inclusion Criteria: * Women with gynecological cancer receiving carboplatin-based chemotherapeutic regimen * ECOG performance status 0-1 * Normal bone marrow, liver, and renal functions * Can speak and write in Thai language Exclusion Criteria: * Women with nausea or vomiting prior to chemotherapeutic administration * Pregnant women * Women with active infection * Women with bowel obstruction * Women with symptomatic brain metastases * Women who received dopamine receptor antagonists within 1 week before chemotherapeutic administration * Women who received corticosteroid within 1 week before chemotherapeutic administration * Women with past history of chemotherapy or radiotherapy * Women with psychiatric disorders * Women with poor controlled diabetes mellitus * Women who received anticonvulsant medication * Women with history of neuroleptic malignant syndrome * Women with history of olanzapine allergy * Women with history of lactose intolerance