Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity

Mayo Clinic60 enrolled

Overview

This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity, Morbid NASH - Nonalcoholic Steatohepatitis Chronic Inflammation

Interventions

Bariatric surgeryPROCEDURE

Evaluate liver fibrosis by elastography before gastric bypass surgery.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Undergoing gastric bypass surgery * Confirmed AUROC F=0 or F\>2 liver fibrosis * Age 30-70 years * BMI greater than 40 kg/m2 * Negative pregnancy test (female only) * Lab Values: Normal TSH Exclusion Criteria: * Autoimmune diseases * Hepatitis B or C positive * Heavy alcohol use * Active smoking history * Active cancer history * History of asthma * History of COPD * Taking Plavix or Coumadin * Blood donation within past 2 months * Glucocorticoid Therapy * Taking antihistamine on regular basis

Locations (1)

Mayo Clinic in Arizona

Scottsdale, Arizona, United States

RECRUITING

Outcomes

Primary Outcomes

Liver fibrosis

evaluate the liver fibrosis by elastography before surgical intervention

Time frame: Baseline

Adipose tissue inflammation

Evaluate markers of adipose tissue inflammation by mRNA levels

Time frame: Baseline

Central Contacts

Keegan M Stewart

CONTACT

480-301-4164 stewart.keegan@mayo.edu

Data from ClinicalTrials.gov

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