Investigation of Vasodilation and Intensity of Headache Triggered by Glucagon Like Peptide-1 in Humans

Criteria for the healthy volunteers group Inclusion Criteria: * Healthy men/women. * Age 18 to 60 years old. * Weight 50 to 100 kg. Exclusion Criteria: * Tension headache more than 5 days a month in the preceding year. * All other primary headache types. * Headache on the examination day or within 48 hours before infusion of the study drug. * Smoking. * Daily intake of medicine of any kind except for peroral contraceptives. * Women, who on the day of examination is 2 days before or 3 days from the first day of bleeding. * Hypertension or hypotension. * Coronary heart disease of any kind, as well as cerebrovascular disease. * Pulmonary disease. * Allergy to contents in the study drug. * Psychiatric disease or substance abuse. * Disease of any kind which the examining doctor deems relevant for participation in the study. * Renouncing the right to information concerning own health. Criteria for the migraine patients group Inclusion Criteria: * Migraine patients, who fulfill the ICHD-3 criteria for migraine without aura. * Age 18 to 60 years old. * Weight 50 to 100 kg. Exclusion Criteria: * Tension headache more than 5 days a month in the preceding year. * All other primary headache types. * Headache on the examination day or within 48 hours before infusion of the study drug. * Smoking. * Daily intake of medicine of any kind except for peroral contraceptives. * Women, who on the day of examination is 2 days before or 3 days from the first day of bleeding. * Hypertension or hypotension. * Coronary heart disease of any kind, as well as cerebrovascular disease. * Pulmonary disease. * Allergy to contents in the study drug. * Psychiatric disease or substance abuse. * Disease of any kind which the examining doctor deems relevant for participation in the study. * Renouncing the right to information concerning own health.