Southeast Asian Brugada Syndrome Cohort

Chulalongkorn University750 enrolled

Overview

Brugada syndrome (BrS) is the leading cause of sudden death in young Asian adults including Thailand. This syndrome may be hereditary and involve mutations in certain genes. Aim of the study is to identify the relationship between genetic variants and the diagnosis/clinical severity of patients with BrS.

This cohort study recruits BrS patients with confirmed Brugada type 1 ECG and healthy volunteers in Thailand. Data collection consists of demographic, clinical data, ECG and blood sample for genetic studies. Genotyping was done by whole genome sequencing and SNP array then compared between cases and controls. Each BrS patient will be followed up prospectively for symptoms and AICD shock. Subsequently, the study will analyze relationship between genetic variants and clinical data against clinical severity of BrS patients.

Study Type

OBSERVATIONAL

Enrollment

750

Conditions

Brugada Syndrome

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Thai nationality * The patient has at least one of confirmed Brugada type 1 ECG in at least one of right precordial leads (v1 or v2) with or without pharmacologic provocative testing. The confirmed ECG is standard 12 lead ECG or Brugada lead Exclusion Criteria: * The patient has other cardiac diseases such as ischemic heart disease, valvular heart disease, congenital heart disease, myocarditis and pericarditis * The patient has type 2 or type 3 Brugada ECG without type 1 ECG during pharmacologic provocative testing and/or Brugada lead * The patient had one time of Brugada type 1 ECG during drug use without reproducibility

Locations (11)

Siriraj Hospital, Mahidol University

Bangkok Noi, Bangkok, Thailand

RECRUITING

Vajira Hospital

Dusit, Bangkok, Thailand

RECRUITING

Outcomes

Primary Outcomes

Relationship between genetic variants and Brugada syndrome (Brugada syndrome phenotype)

Case-Control study of genetic variants in BrS cases vs controls. Genetic study was done by whole genome sequencing and SNP array. Association analysis assessed by polygenic risk score and regression coefficients.

Time frame: 7 years

Secondary Outcomes

Natural history of Brugada syndrome (survival from arrhythmic events)

Cohort study to followed up BrS patients with or with arrhythmic events which assessed by survival curve analysis.

Time frame: 7 years

Epidemiology of Brugada syndrome

To study prevalence of Brugada syndrome in Thailand.

Time frame: 7 years

Central Contacts

Apichai Khongphatthanayothin, MD

CONTACT

66891555545 apichaik@yahoo.com

Pharawee Wandee, BSc

CONTACT

66944174331 brugadaproject@gmail.com

Data from ClinicalTrials.gov

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