Clinical Study of in Situ Regeneration of Endometrium

Inclusion Criteria: 1.Patients with thin endometrium (4mm≤ EMT \<7mm )or scarred endometrium (scarred area≤70%) which is nonresponsive to estrogen stimulation 2.Infertile patients with clear fertility desires 3.20-42 years old 4.Normal ovarian function or with frozen embryos 5.Willing to participate in follow-up Exclusion Criteria: 1. Endometrial thickness \<4mm or scarred endometrial area\>70% 2. Uterine cavity out of shape and the cavity depth\<6.5mm 3. Abnormal chromosome karyotype 4. Uterine diseases including large intramural myomas, severe endometriosis, severe adenomyosis, severe congenital uterine malformations, endometrial tuberculosis, vaginitis and endometritis 5. Systemic diseases: hypertension, diabetes, and so on 6. Contraindications to pregnancy 7. Contraindications to hormone replacement therapy 8. Medical history of pelvic tumors or receiving pelvic radiotherapy 9 .Involved in other clinical studies 10\. Unable to adhere to the follow-up