Continuous Infusion and Bolus Doses of Rocuronium During Lumbal Discectomy, Muscle Strength and Patient Recovery

Clinical Hospital Centre Zagreb80 enrolled

Overview

The continuous infusion of rocuronium during general anesthesia for a lumbar discectomy enables better muscle strength recovery, and a better quality of patient recovery as measured by questionnaire.

Rocuronium is a non-depolarising neuromuscular blocking agent that can be administered in bolus doses or via continuous infusion during general anesthesia. Due to the specificity of the knee-chest position in a lumbar discectomy, many complications during anesthesia and surgery are possible. Therefore an effective and balanced intraoperative neuromuscular block is needed. Studies so far have not included a comparison on muscle strength and quality of patient recovery of the effect of continuous infusion and bolus doses of rocuronium during anesthesia for lumbar discectomy. The hypothesis of this research was that the continuous infusion of rocuronium during general anesthesia for a lumbar discectomy enables better muscle strength recovery, and a better quality of patient recovery as measured by questionnaire. The aim was to compare the influence of the continuous infusion and bolus doses of rocuronium on patient recovery. Therefore the investigators assessed how continuous infusion and bolus doses of rocuronium affect the recovery of muscle strength as measured by a hand-grip dynamometer. The quality of patient recovery was assessed by standardised questionnaire (Qor-40 - Quality of recovery questionnaire). The aim was also to evaluate the applicability of the Croatian version of Qor-40 questionnaire in clinical practice.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Rocuronium Lumbar Discectomy Recovery

Interventions

RocuroniumDRUG

Rocuronium administered in continuous infusion or multiple bolus doses

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA ( American Society of Anesthesiologists) grading status I-III * scheduled for lumbal discectomy under general anesthesia * signed informed consent for participating in the research Exclusion Criteria: * neuromuscular disease * poorly controlled chronic or acute cardiovascular, respiratory or autoimmune disease * allergic reaction to any of the medications in protocol * pregnancy * refusal to participate in the research

Locations (1)

UHCZagreb

Zagreb, Croatia

Outcomes

Primary Outcomes

Change in muscle strength

Change in muscle strength between groups measured my hand-grip dynamometer on three occasions: before general anesthesia, in the early post-anesthesia period in the operating room, and 24 hours after anesthesia.

Time frame: perioperative

Change in quality of patient recovery

Change in quality of recovery between groups measured with Qor-40 questionnaire. The quality of patient recovery was assessed with a Qor-40 questionnaire before anesthesia, 24 hours after anesthesia, and 30 days after anesthesia and surgery.

Time frame: up to 24 weeks

Secondary Outcomes

Validation of Croatian version of the quality of recovery questionnaire (Qor-40)

Translate to croatian language the quality of recovery questionnaire according to Beaton and Bullinger docrtine and evaluate the applicability of the Croatian version of Qor-40 questionnaire in clinical practice in croatian speaking area

Time frame: perioperative

Data from ClinicalTrials.gov

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