The Effect of Remifentanil on Rebound Pain

Seoul National University Hospital68 enrolled

Overview

The investigators will evaluate the influence of intraoperative remifentanil infusion on the postoperative hyperalgesia in patients receiving rotator cuff repair after brachial plexus block for postoperative analgesia.

The study will include 68 patients undergoing rotator cuff repair. All patients will receive brachial plexus block for postoperative analgesia, followed by general anesthesia. In the experimental group, remifentanil infusion will not be used intraoperatively, and in the control group, remifentanil will be infused. After surgery, both groups will be given the same postoperative pain management using patient controlled analgesia(PCA), and pain patterns will be assessed using the Numerical rating scale (NRS) at 4 hour intervals for 24 hours. The primary end point of this study is the total dose of PCA medication over 24 hours.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Pain, Postoperative

Interventions

Not used remifentanil infusionDRUG

Remifentanil is not used during operation

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ASA class I,II,III * Patients undergoing arthroscopic rotator cuff repair surgery under general anesthesia after interscalen brachial plexus block for post operative analgesia * Age ranges from 20 to 70 Exclusion Criteria: * Patients who didn't agree to study * Patients can't control PCA(Patient-Controlled-Analgesia) independently * Patients who have conciousness disorder or can't express their pain level by NRS(Numeric Rating Scale) system * Patients who have severe respiratory disease or hepatic failure * Patinets who have known neuropathy or coagulopathy * Pregnancy * Patients with allegies to the drugs used in this study

Locations (1)

Jin-Tae Kim

Seoul, South Korea

Outcomes

Primary Outcomes

Total infused dose of patient controlled analgesia(PCA) drug during 24 hours

Total infused dose of patient controlled analgesia(PCA) drug during first 24 hours after rotor cuff repair under general anesthesia

Time frame: From end of operation to the 24hours after operation

Secondary Outcomes

Numerical Ratings Scale

Degree of pain is assessed using Numerical Ratings Scale at 4 hours for 24 hours after operation. The patients choose one of the digits from 0 to 10, the zero-point is painless, and the ten-point means the one with the most severe pain.

Time frame: Pain levels are checked using Numerical Ratings Scale at 4 hour intervals for 24 hours after surgery

Total patient's trial to PCA bolus infusion

The total number of times patients press the infusion button on the PCA to control pain

Time frame: 24 hours after surgery

Incidence of postoperative nausea and vomiting

Postoperative nausea and vomiting is assessed at 24hr after surgery by a face-to face interview

Time frame: 24 hours after surgery

Data from ClinicalTrials.gov

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