Efficacy and Safety of Angong Niuhuang Wan for Stroke

Inclusion Criteria: 1. Chinese adults aged 40 or above; 2. diagnosed as a stroke by a neurologist, with imaging of CT or MRI support; 3. Neurologist confirms the symptoms of stroke occur within 28 days and are clinically stable. In the past 48 hours, the condition of the nervous system has not deteriorated significantly; 4. TCM diagnosis is a stroke and belongs to a heat syndrome; 5. There is a movement defect caused by stroke; 6. The severity of stroke was scored 5-25 by the National Institutes of Health Brain Stroke Scale (NIHSS); 7. Informed consent will be given by participant or its representatives Exclusion Criteria: 1. The movement defects are not associated with stroke. Before commencement of study treatment, patient has physical activity dysfunction caused by lameness , osteoarthritis, rheumatoid arthritis, gouty arthritis, etc. that may affect neurological function examination; 2. Subjects are unlikely to come back for follow-up visits during the 24-week study period; 3. The subject has a brain tumor on a computed tomography scan (CT); 4. The subject has thrombocytopenia (known platelet count \<100,000 / mm3) or coagulopathy disease; 5. Taking warfarin or other anticoagulant; 6. Concomitant diseases such as severe hypertension or diabetes; 7. Comorbidities or complications associated with drug evaluation; 8. Pregnant or breast-feeding female. 9. The alanine aminotransferase (ALT) value is 1.5 times higher than the normal maximum value in liver function test and the estimated glomerular filtration rate (eGFR) \<30 ml/min/1.73 m2 in the renal function test. 10. Present the sign of pure yin syndrome or yin / yang defecation in TCM diagnosis; 11. Subject has G6PD 12. Known swallowing problem 13. Dependent in all daily life activities