Source-monitoring is a cognitive process that refers to the ability to remember the source of an information. Some studies have showed source-monitoring deficits in patients with schizophrenia as well as in individuals at ultra-high risk for psychosis (UHR) and in first-episode psychosis patients (FEP). Source-monitoring deficits have thus been proposed as a potential early risk factor for psychosis. However, further studies are needed to better characterize this deficit. The aim of this project is to investigate source-monitoring performances in UHR, FEP patients and healthy controls (HC) and to characterize these deficits in terms of brain anatomy, basic auditory processes and social functioning.
Ninety participants will be included in the study: 30 UHR, 30 FEP and 30 healthy controls. All the participants will complete a standardized source-monitoring task, an MRI acquisition (3D-T1 anatomical scan), a tone-matching task as well as a socio-demographic and clinical evaluation including an assessment of the social functioning.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
90
comparison of cognitive performances and brain anatomy
Centre Hospitalier le Vinatier
Bron, France
NOT_YET_RECRUITINGCentre Hospitalier le Vinatier
Bron, France
RECRUITINGSource-monitoring performances
Scores obtained at a source-monitoring task (Brunelin et al., 2006)
Time frame: one day
Confidence in source-monitoring judgements
Confidence in source-monitoring judgements will be measured using a visual analogue scale (0-100)
Time frame: one day
Grey matter volume
Grey matter volume will be assessed with a structural MRI scan (3D-T1) followed by morphometry analyses.
Time frame: one day
Brain gyrification
Brain gyrification will be assessed with a structural MRI scan (3D-T1) followed by gyrification analyses.
Time frame: one day
Basic auditory performances
scores at the Tone Matching Task (Strous et al., 1995)
Time frame: one day
Working memory performances
scores at a working memory task (Barrouillet et al., 2004)
Time frame: one day
Social functioning
score at the "personal and social performance scale" (0-100)
Time frame: one day
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