Every lunar year, during the month of Ramadan, Muslims abstain from food and drink between dawn and nightfall. People with type 2 diabetes who fast during Ramadan are at an increased risk of acute glycemic complications. Our aim is to investigate the effect of dosage reduction of four glucose-lowering multidrug regimens on the incidence of acute glycemic complications in people with type 2 diabetes who fast during Ramadan.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
687
* Metformin (PO; 850 mg; BID \[with Ifṭār and with Suḥūr\]) * Glimepiride (PO; 1.5 or 3 mg \[75% of the pre-Ramadan dose\]; OD \[with Ifṭār\])
* Metformin (PO; 850 mg; BID \[with Ifṭār and with Suḥūr\]) * Vildagliptin (PO; 50 mg; OD \[with Ifṭār\])
* Metformin (PO; 850 mg; BID \[with Ifṭār and with Suḥūr\]) * Insulin Glargine U100 (SC; 9-33 units \[75% of the pre-Ramadan dose\]; OD \[at 10 P.M.\])
Jordan University Hospital
Amman, Amman Governorate, Jordan
Hypoglycemia
Incidence of hypoglycemia
Time frame: 29 days of Ramadan
Hyperglycemia
Incidence of hyperglycemia
Time frame: 29 days of Ramadan
Diabetic ketoacidosis
Incidence of diabetic ketoacidosis
Time frame: 29 days of Ramadan
Hyperosmolar hyperglycemic state
Incidence of hyperosmolar hyperglycemic state
Time frame: 29 days of Ramadan
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
* Metformin (PO; 850 mg; BID \[with Ifṭār and with Suḥūr\]) * Insulin Glargine U100 (SC; 6-39 units (75% of the pre-Ramadan dose); OD \[at 10 P.M.\]) * Human Regular Insulin (SC; 15-33 units before Ifṭār and 6-18 units before Suḥūr \[75% of the pre-Ramadan doses\])
* Metformin (PO; 850 mg; BID \[with Ifṭār and with Suḥūr\]) * Glimepiride (PO; 2 or 4 mg \[100% of the pre-Ramadan dose\]; OD \[with Ifṭār\])
* Metformin (PO; 850 mg; BID \[with Ifṭār and with Suḥūr\]) * Vildagliptin (PO; 50 mg; BID \[with Ifṭār and with Suḥūr\]\])
* Metformin (PO; 850 mg; BID \[with Ifṭār and with Suḥūr\]) * Insulin Glargine U100 (SC; 11-44 units \[100% of the pre-Ramadan dose\]; OD \[at 10 P.M.\])
* Metformin (PO; 850 mg; BID \[with Ifṭār and with Suḥūr\]) * Insulin Glargine U100 (SC; 8-52 units (100% of the pre-Ramadan dose); OD \[at 10 P.M.\]) * Human Regular Insulin (SC; 12-40 units before Ifṭār and 7-28 units before Suḥūr \[100% of the pre-Ramadan doses\])