The Evaluation of Chenopodium Formosanum and Fagopyrum Esculentum Extract on Anti-aging Effect

N/ACompletedNCT04237818

TCI Co., Ltd.50 enrolled

Overview

To assess Chenopodium Formosanum and Fagopyrum Esculentum Extract on skin anti-aging

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Skin Condition

Interventions

Placebo drinkDIETARY_SUPPLEMENT

consume 2 bottle (30 mL) per day for 56 days

Chenopodium Formosanum and Fagopyrum Esculentum Extract drinkDIETARY_SUPPLEMENT

consume 2 bottle (30 mL) per day for 56 days

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy adults aged between 20-65 years old * Subjects must read and sign the informed consent form after the study has been fully explained. * Subjects are willing to cooperate and comply with all of the regulation during the trial. * Subject should inform to investigator immediately if adverse effect is happened. * Subjects are willing to avoid UV overexposure during the trial (include indoor tanning treatment). Exclusion Criteria: * Subjects who have known cosmetic, drug or food allergies. * Subjects who have severe desquamation, tattoo, sunburn, peeling skin or other skin condition might impact measurement. * Subjects with any physical condition judged by the researcher not to be eligible for this study. * Subjects with uncontrollable physical condition such as high blood pressure, thyroid disease, diabetes, etc. * Female who is pregnant or nursing or planning to become pregnant during the course of the study. * Those who are currently participating in other clinical trials or who have just concluded a clinical trial two weeks ago. * Women who have started contraceptive or change current hormone contraceptive methods within 3 months.

Locations (1)

China Medical University

Taichung, Taiwan

Outcomes

Primary Outcomes

The change of skin moisture

Corneometer® CM825 is utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120

Time frame: Change from Baseline skin moisture at 8 weeks

The change of skin elasticity

Cutometer® dual MPA 580 is utilized to measure skin elasticity (parameter R2). Units: μm penetration depth into the probe opening, expressed as curves

Time frame: Change from Baseline skin elasticity at 8 weeks

The change of skin wrinkles

3D Full-Face Skin Analyzer IRV is utilized to measure wrinkles. Units: arbitrary units

Time frame: Change from Baseline skin wrinkles at 8 weeks

The change of skin collagen density

DermaLab® combo - 20 MHz High Freq. Ultrasound probe is utilized to scan and analyze skin collagen density. Units: Intensity score

Time frame: Change from Baseline skin collagen density at 8 weeks

The change of skin tone

3D Full-Face Skin Analyzer IRV was utilized to measure skin tone. Units: arbitrary units

Time frame: Change from Baseline skin tone at 8 weeks

The change of skin brightness

3D Full-Face Skin Analyzer IRV is utilized to measure skin brightness. Units: arbitrary units

Time frame: Change from Baseline skin brightness at 8 weeks

The change of skin melanin index

Mexameter® MX 18 is utilized to measure skin melanin index. Units: arbitrary Mexameter® units (0-999)

Time frame: Change from Baseline skin melanin index at 8 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

Secondary Outcomes

The change of transepidermal water loss (TEWL)

Tewameter® TM 300 is utilized to measure transepidermal water loss. Units: g/hm²

Time frame: Change from Baseline TEWL at 8 weeks

The change of skin texture

3D Full-Face Skin Analyzer IRV is utilized to measure skin texture. Units: arbitrary units

Time frame: Change from Baseline skin texture at 8 weeks

The change of skin pores

3D Full-Face Skin Analyzer IRV is utilized to measure skin pores. Units: arbitrary units

Time frame: Change from Baseline skin pores at 8 weeks

The change of skin spots

3D Full-Face Skin Analyzer IRV is utilized to measure skin spots. Units: arbitrary units

Time frame: Change from Baseline skin spots at 8 weeks

The change of skin erythema level

Mexameter® MX 18 is utilized to measure skin erythema level. Units: arbitrary Mexameter® units (0-999)

Time frame: Change from Baseline skin erythema level at 8 weeks

Self-assessment questionnaire

Questionnaire is utilized to assess skin condition of the subjects. Units: score

Time frame: 8 weeks