Video-assisted thoracoscopic (VATs) lobectomy is mild to moderately pain procedure. For conventional thoracotomy, there are many invasive pain control such as epidural analgesia, paravertebral block. However, for VATs, the invasive pain control somehow are too invasive. Nefopam is non-opioid painkilling medication, Serotonin, norepinephrine, dopamine reuptake inhibitor. Many study were demonstrated positive outcome of nefopam usage in many operation such as abdominal surgery, laparocopic surgery, orthopedic surgery. Nevertheless, nefopam for VATs is not well studied yet.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
72
Nefopam group nefopam 20 mg during surgery and follow by 80 mg in 24 hours postoperative
Placebo
faculty of medicine Siriraj hospital
Bangkok, Thailand
morphine consumption in first 24 hours post-operative
morphine consumption record from patient-controlled analgesia machine in 24 hours post-operative
Time frame: 24 hours
numeric pain score
numeric pain score in 1, 2, 12, 24 hours after surgery
Time frame: 24 hours
side effect of nefopam
side effect of nefopam: tachycardia, sweating, nausea, vomiting, sedation
Time frame: 24 hours
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