In a spanish series of AML patients it is intended to perform, at the moment of diagnosis, pyrosequencing of IDH1 and IDH2 genes. Taking into account the incidence of AML in the area, it is planed to study 100 patients per year. Among the cases with IDH1/2 mutations, targeted deep sequencing (TDS) of a panel covering coding regions of 40 myeloid related genes will be applied. With TDS, pyrosequencing results will be validated at the same time that prognosis value of co-mutated genes could be studied. Furthermore, with TDS, molecular architecture of IDH1 and IDH2 mutated cases might be better understood.
Study Type
OBSERVATIONAL
Enrollment
354
Presence of IDH1/2 mutation
Detection of mutations in IDH1 and IDH2 genes
Time frame: 1 day
Detection of co-mutations
Screening of aditional mutations in those cases with IDH1/2 mutation
Time frame: 1 day
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