To compare efficacy of oral steroid in controlling pain after TKA
To compare pain and functional outcome for oral dexamethasone 16 mg, 8 mg and pacebo in patient undergoing unilateral primary total knee arthroplasy
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
40
To compare oral dexamethasone 16 mg vs 8 mg vs placebo in pateints undergoing unilateral TKA
department of orthopaedic surgery, Faculty of medicine, Thammasat university
Khlong Luang, Changwat Pathum Thani, Thailand
RECRUITINGPain level
VAS for pain (0-100) at rest and on motion
Time frame: 12, 24 ,36, 48, 60 and 72 hours after surgery
nausea and vomiting
rate of nausea and vomiting
Time frame: in the first 72 hours after surgery
Range of motion of the knee
Flexion and extension angle
Time frame: 24, 72 hours then 2, 6, 12 weeks after surgery
Functional outcome
Modified WOMAC score
Time frame: 2, 6,12 weeks after surgery
Blood sugar
Fasting blood sugar level
Time frame: At 8.00 am of 1, 2, 3 days after surgery
inflammatory level
C-reactive protein level
Time frame: At 8.00 am of 1, 2, 3 days and 2 weeks after surgery
Wound complications
Deep and superficial wound infection, wound dehiscense
Time frame: 3 months after surgery
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