The purpose of this study is to determine the effectiveness of antiangiogenic therapy to choroidal neovascularization secondary to central chorioretinitis.
The purpose of this study is to determine the effectiveness of antiangiogenic therapy to choroidal neovascularization secondary to central chorioretinitis. This study is planned as a follow-up. Patients with central chorioretinitis included in it will receive antiangiogenic therapy in accordance with the approved indications for use indicated in the instructions for the use of drugs in Ukraine. The treatment proposed in this study is based on the world experience and scientific developments of the Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine ". Therefore, it is expected that the benefit / risk ratio in relation to the participation in this study should not be different from that described in the scientific literature and the benefits outweigh the risk. It is known that the absence of treatment in these diseases leads to an irreparable loss of central vision.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Intravitreal injection of Aflibercept 2 mg (0.05 ml) or Ranibizumab 0.5 mg (0.05 ml) to the regimen pro re nata.
Ophthalmic examination
Ophthalmic examination
Mykolaiv Region Ophthalmogical Hospital
Mykolaiv, Ukraine
RECRUITINGOdessa National Medical University
Odesa, Ukraine
RECRUITINGThe Filatov Institute of Eye Diseases and Tissue Therapy
Odesa, Ukraine
RECRUITINGMean Change in Best Corrected Visual Acuity (BCVA) as Measured by ETDRS Chart
Defined study baseline range of ETDRS equivalent of 20/200 to 20/20) in the study eye; a higher score represents better functioning.
Time frame: Baseline-Month 12
Mean Change in Central Retinal Thickness (CRT) as Assessed by Optical Coherence Tomography (OCT)
A negative number indicates improvement (reduced thickness).
Time frame: Baseline-Month 12
Average Number of Intravitreal Injections
The number of intravitreal injections administered
Time frame: Baseline-Month 12
Number of Endophthalmitis after Intravitreal Injections
The number of endophthalmitis registered in patients after intravitreal injections
Time frame: Baseline-Month 12
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Ophthalmic examination
Ophthalmic examination
Ophthalmic examination
Ophthalmic examination