Lidocaine Patch 1.8% for Moderate to Severe Pain From Carpal Tunnel Syndrome

Inclusion Criteria: Participants must meet all of the following inclusion criteria to be eligible for enrollment into the study: * Male and female participants, 18 years or older at Screening; * Participants with Carpal Tunnel Syndrome, confirmed by CT6; * Pain score of at least 4, based on an 11-point numeric rating scale (NRS) (scale of 0-10), at the screening (baseline) visit; * Able and willing to provide a written informed consent; * Able and willing to follow study instructions; * Able and willing to return to clinic for follow-up visits; * Able and willing to complete a daily diary; * Intact skin over the affected wrist; * Woman of childbearing age agreeing to use 2 forms of contraception. Exclusion Criteria: Participants presenting with any of the following exclusion criteria will not be enrolled into the study * Participants must NOT have had prior steroid injection for CTS, CTS surgery, or other intervention/injury to the wrist that might interfere with assessments in the previous 30 days; * Participants must not have pain at other sites that interfere with their ability to report site-specific pain related to the study (bilateral CT is an exclusion); * Participants must NOT have cognitive or psychological impairment that interferes with the ability to complete study related assessments; * Participants with mild (NRS less than 4) or no pain (only numbness) at baseline prior to randomization; * Opioid tolerance (receiving at least 1 week of oral morphine 60 mg/day OR transdermal fentanyl 25 mcg/hour OR oral oxycodone 30 mg/day OR oral hydromorphone 8 mg/day OR an equianalgesic dose of any other opioid); * History of sensitivity or allergy to lidocaine or ZTLIDO; * Irritated, abraded, or otherwise non-intact skin over the affected wrist; * Concurrently taking tocainide, mexiletine, or local anesthetics; * Participants with history of or at significant risk for methemoglobinemia; * Participation in another study of investigational drugs or devices within 30 days before screening, or previous participation in a Lidocaine Patch study; * Known to or suspected of not being able to comply with the study protocol; * Any clinically significant condition that would, in the investigator's opinion, preclude study participation for instance alcohol, medication or drug dependency, neurotic personality, psychiatric illness, epilepsy or suicide risk; * Pregnancy or nursing mother; * Woman in childbearing age without satisfactory contraception; * Presence of possible other cause/s for hand pain (i.e., radicular pain, arthritis, injury, surgery) that could confound assessment or self-evaluation of the pain due to Carpal Tunnel Syndrome; * Participants using topically applied analgesic compounds on the affected area;