Bone reconstruction in critical sized defect (CSD) remains a real challenge in orthopedic surgery in children and adults. The Masquelet technique is an innovative therapeutic technique, which offers a bone reconstruction in two steps, by the formation of an induced membrane (IM) around a polymethylmethacrylate (PMMA) spacer placed into the bone defect. After, PMMA removal, the cavity is filled with corticocancellous graft allowing bone healing. Up to date, all angiogenesis and osteogenic properties of IM remain unknown. The purpose of this study is to characterize angiogenesis and osteogenic properties of IM in children and adults.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
50
The induced membrane will be harvested during the second step of the bone reconstruction.
CHU Amiens
Amiens, France
RECRUITINGMeasure of the BMP2 concentration of the induced membrane by immunodetection
Measure of the osteogenic property of the induced membrane will be made after harvesting the induced membrane
Time frame: one year (one year from day of surgery)
BMP2 concentration of the induced membrane implanted in adults measured by immunodetection
measurement of osteogenic property of the induced membrane in adults
Time frame: one year (one year from day of surgery)
BMP2 concentration of the induced membrane implanted in children measured by immunodetection
measurement of osteogenic property of the induced membrane in children
Time frame: one year (one year from day of surgery)
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