The purpose of this study was to determine whether disconnecting pulmonary vagus nerve branch can abatement chronic cough in patients undergoing unilateral thoracoscopic lobectomy,compared with preserving pulmonary vagus nerve branch.
After screening for the Inclusion criteria and the exclusion criteria, 116 patients undergoing unilateral thoracoscopic lobectomy are randomly assigned to two groups, disconnecting pulmonary vague nerve branches and preserving pulmonary vague nerve branches. The incidence of chronic cough after surgery is compared between groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
116
When the operation is in the right side, the Azygous vein bow is used as the marker, and in the left side, the aortic arch is used as the marker to identify the vagus nerve trunk.Then the surgeons dissect the vagus nerve trunk. This is used as a clue to find the vagus nerve pulmonary branch leading to the hilum. The position of the detachment is after the anterior and posterior pulmonary branches of the vagus nerve separating from the trunk and before the formation of the lung plexus.
Department of Anesthesiology of the Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China
The incidence of chronic cough after surgery
More than 8 weeks after surgery, there is no clear cause of cough with stable chest CT excluding the diagnosis of postnasal drip syndrome, asthma or the use of Angiotensin-converting enzyme inhibitor(ACEI), etc.
Time frame: 3 months after surgery
The incidence of chronic cough after surgery
More than 8 weeks after surgery, there is no clear cause of cough with stable chest CT excluding the diagnosis of postnasal drip syndrome, asthma or the use of Angiotensin-converting enzyme inhibitor(ACEI), etc.
Time frame: 1 month after surgery
The score of the LCQ-MC scale after surgery
The LCQ-MC was designed for the assessment of a chronic cough, consists of 19 items and three domains.
Time frame: 1 month and 3 months after surgery
Length of operation
Time frame: during the operation
volume of bleeding
Time frame: during the operation
volume of postoperative drainage
Time frame: within 30 days after surgery
the frequence of perioperative arrhythmia
Time frame: during the operation
the incidence of Postoperative complication
pulmonary complications, intestinal obstruction, pulmonary embolism, acute respiratory failure, acute renal failure, wound infection, cerebrovascular accident
Time frame: within 30 days after surgery
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the score of Cough symptom
The score was used to record daily symptom score for cough severity.The scale is scored by 4 levels at day and night respectively.The higher score means worse symptom.
Time frame: postoperative 1 day,2 days,3 days,4 days,5 days,6 days
the time of extubation
Time frame: within 30 days after surgery
the incidence of gastrointestinal symptoms
gastrointestinal symptoms include anorexia, belching, reflux, diarrhea, nausea
Time frame: within 3 months after surgery
the incidence of postoperative hospitalization
Time frame: within 30 days after surgery
pulmonary function 30 months after surgery
maximal voluntary ventilation, diffusing capacity of the lungs for carbon monoxideand forced expiratory volume
Time frame: 30 months after surgery