Optimal Timing of BR55 CEUS of the Ovaries

Inclusion Criteria: Enroll a subject in this study if the subject meets the following inclusion criteria: * Is a female subject of at least 18 years of age; * Is premenopausal; * Is scheduled to undergo preventative salpingo-oophorectomy for high risk of ovarian cancer not earlier than 24 hours and not later than 5 days following the second BR55 CEUS examination; * Provides written Informed Consent and is willing to comply with protocol requirements. Exclusion Criteria: Exclude a subject from this study if the subject does not fulfill the inclusion criteria, or if any of the following conditions are observed: * Is a pregnant or lactating female. Exclude the possibility of pregnancy: * by testing on site at the institution (serum βHCG) within 24 hours prior to the start of investigational product administration, * by surgical history (e.g., tubal ligation or hysterectomy), * Has undergone prior systemic therapy for ovarian cancer; * Has history of concurrent malignancy; * Has history of any clinically unstable cardiac condition including class III/IV congestive heart failure; * Has had any severe cardiac rhythm disorders within 7 days prior to enrolment; * Has severe pulmonary hypertension (pulmonary artery pressure \>90mmHg) or uncontrolled systemic hypertension and/or respiratory distress syndrome; * Has open and/or non-healing wounds in the chest, abdomen and pelvis; * Has other systemic vascular abnormalities associated with neovascularization that in the opinion of the investigator could significantly affect the ability to evaluate the effects of BR55; * Is participating in a clinical trial or has participated in another trial with an investigational compound within the past 30 days prior to enrolment; * Has previously been enrolled in and completed this study; * Has any known allergy to one or more of the ingredients of the Investigational Product or to any other contrast media; * Is determined by the Investigator that the subject is clinically unsuitable for the study; * Has had major surgery, including laparoscopic surgery, within 3 months prior to enrolment; * Has history of surgery to the ovaries or pelvic inflammatory disease.