DENEX Renal Denervation in Patients With Uncontrolled Hypertension: Safety Study

Inclusion Criteria: 1. Individual is ≥ 20 years of age at time of consent 2. Individual has office systolic blood pressure (SBP) of ≥ 150 mmHg 3. Individual has daytime 24-hour Ambulatory Blood Pressure Monitoring (ABPM) SBP of ≥ 140 mmHg 4. Individual maintains the following 3 antihypertensive medications: thiazide-type diuretic, calcium-channel blocker, and angiotensin-converting enzyme inhibitor or angiotensin receptor blocker (for at least 6 weeks before the screening visit) that is expected to be maintained without changes for at least 6 months. Exclusion Criteria: 1. Main renal artery contains renal artery stenosis \>50% 2. Individual has confirmed anatomical findings in kidneys or renal arteries through CT scan or angiogram 3. Undergone prior renal angioplasty 4. Main renal arterial vessel for each kidney \<4 and \>8 mm in diameter, or \<20 mm length 5. Individual has an Estimated glomerular filtration rate \<45 mL/min/1.73 m2 at screening visit 6. Individual has experienced myocardial infarction, unstable angina pectoris, syncope, or a cerebrovascular accident within 3 months of the screening period, or has widespread atherosclerosis, with documented intravascular thrombosis or unstable plaques 7. Individual has Hemodynamically or echocardiography significant valvular heart disease 8. Individual has secondary hypertension (pheochromocytoma, Cushing syndrome,coarctation of the aorta, renovascular hypertension, primary hyperaldosteronism, or other secondary hypertension) 9. Individual has documented primary pulmonary hypertension 10. Individual has orthostatic hypotension with symptom 11. Individual requires chronic oxygen support for sleep apnea 12. Individual is taking chronic NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). Only, Aspirin is permitted for cardiovascular disease prevention 13. Individual has Type 1 diabetes mellitus