Quantitative MRI for Functional Assessment Following SBRT for Spinal Metastases

Inclusion Criteria: * A diagnosis of metastatic cancer with a vertebral body metastasis or contiguous vertebral body metastases for which SBRT is appropriate * Age ≥ 18 years of age * KPS ≥ 70 * Life expectancy of at least 3 months * No contraindication to undergoing MR imaging * Women of childbearing age must have a negative urine or serum pregnancy test to meet eligibility per Duke Policy * Pre-treatment pain score of at least 1/10 based on the numeric pain rating scale (NPRS) * Disease located from C1 to S5 * Subjects with prior radiation to the involved vertebral body are allowed. Exclusion Criteria: * Subjects unable to undergo MRI (includes non-MRI compatible material or devices and severe claustrophobia) * Subjects with prior procedural intervention to the involved vertebral body that would result in artifact (kyphoplasty, screw and/or rod placement); minimally invasive surgery without instrumentation of the involved vertebral body and instrumentation immediately above or below the index lesion is allowed. * Subjects with spinal cord compression; minimally invasive "separation" surgery to first resect the epidural component is allowed * Pregnant or breast-feeding women * Allergy to standard IV contrast agents used in MRI * Subjects with eGFR \<30 30 mL/min2 or on dialysis