Goals: To explore the association of probability of pregnancy with certain prognostic factors in patients undergoing assisted reproductive technology in Russian population according to international and national guidelines.
Research on significant factors (predictors) of pregnancy rate in In Vitro Fertilization (IVF) and Intracytoplasmatic Sperm Injection (ICSI) cycles in Russian population according to actual national and international guidelines in patients using oral dydrogesterone for luteal phase support in assisted reproductive technology. Investigating the strength of the relationship and assessing coefficients of impact on the pregnancy rate. Creating a predictive table of Clinical Pregnancy in IVF and ICSI cycles and 4-5 most impact predictors.
Study Type
OBSERVATIONAL
Enrollment
1,150
No intervention. Description of routine practice only. Prescribed Duphaston® according local marketing authorization and international and Russian In-Vitro Fertilization guidelines for luteal phase support as part of an Assisted Reproductive Technology (1 tablet 3 times a day starting at the day of oocyte retrieval).
4-5 predictors with highest impact on the probability of clinical pregnancy as evaluated by a logistic regression model
Evaluating coefficients of the relationship between pregnancy rate and following variables: * female age (years), * female height (cm) / weight (kg) / Body Mass Index (kg/m2), * Antral Follicle Count, * Ovarian Sensitivity Index, * number of top-quality embryos, * pre-implantation genetic testing (performed / not performed), * day of embryo transfer, * treatment history (number of previous attempts), * infertility cause (male factor infertility, endometriosis, endometrial factor, myoma, tubal factor, idiopathic), * endometrial thickness, * serum Anti-Mullerian hormone level, * year, season, * race (Caucasian, Asian, Black) as predictors.
Time frame: 10 weeks
Patient's convenience and global satisfaction
Patient's convenience and global satisfaction of using medication for luteal phase support assessed by Treatment Satisfaction Questionnaire for Medication (TSQM-9). TSQM-9 is a 9-item instrument consisting of 3 scales: effectiveness scale (3 questions), convenience scale (3 questions) and global satisfaction scale (3 questions). The scores were computed by adding items for each domain. The lowest possible score was subtracted from this composite score and divided by the greatest possible score minus the lowest possible score. This provided a transformed score between 0 and 1 that was then multiplied by 100. TSQM-9 domain scores range from 0 to 100 with higher scores representing higher satisfaction on that domain.
Time frame: 2 weeks, 10 weeks
The overall pregnancy rate
The overall pregnancy rate with confirmed clinical pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs, including ectopic pregnancy
Time frame: 10 weeks
The rate of positive biochemical pregnancy test
The rate of positive biochemical pregnancy test (diagnosed by the detection of human chorionic gonadotropin (hCG) in serum or urine on Day 12-14 after embryo transfer).
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Time frame: 2 weeks