This project addresses the problem of adverse drug reactions in the three most frequently prescribed therapeutic classes of drugs in children: antibiotics, analgesics, and mental health medications. We will conduct pilot testing of a pharmacogenomic testing panel and study how the tests and generated test results are utilized and understood by physicians, pharmacists, patients and their families.
The specific objectives are to: 1. Implement a pilot pharmacogenomics program to test medication safety and effectiveness of antibiotics, analgesics and mental health medication to enhance prescribing decision-making. 2. Develop data collection forms to collect necessary patient information from the prescribing physicians. 3. Develop pharmacogenomics reports to return results to physicians, pharmacists, patients and their families. 4. Determine how the tests and results are perceived and utilized by physicians, pharmacists, patients and their families.
Study Type
OBSERVATIONAL
Enrollment
150
Children's and Women's Health Centre of British Columbia
Vancouver, British Columbia, Canada
RECRUITINGChildren's Hospital of Eastern Ontario
Ottawa, Ontario, Canada
RECRUITING150 participants on analgesics, anti-infectives and psychotropics will be given pharmacogenomic recommendations for the risk of gene related adverse events prior to or during treatment.
We will be able to determine the barriers and facilitators of the implementation of the pharmacogenomic service in a health care facility. This will be done by using standardized questionnaires after each pharmacogenomic report is issued. The prescriber and the patient will both answer questions about the utility of the genetic results, the format of the report and the clarity of the content. Results will be recorded and summarized every 25 patients in order to improve the service and the recommendations through the study.
Time frame: June 2020
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