The Incidence of Gallstones After Gastric Cancer Surgery

Hepatopancreatobiliary Surgery Institute of Gansu Province1,019 enrolled

Overview

Through previous clinical observations and literature, we found that the incidence of gallstones in patients after gastric cancer radical resection was significantly higher than that in the normal population (4%). However, its pathogenesis has not been clarified. We compare the risk of gallbladder stones after four different radical gastric cancer surgical methods, in order to provide prevention and treatment strategies for people with gallstones after gastric cancer.

A large number of clinical studies have found that the incidence of gallstones in patients with radical gastric cancer is higher than that in the normal population. However, its pathogenesis has not been clarified, and there is still controversy about the prophylactic removal of gallbladder in patients with gastric cancer. The investigator's previous study found that there was no statistical difference in the incidence of gallstones after laparoscopic distal gastrectomy (LDG), laparoscopic total gastrectomy (LTG) and laparoscopic proximal gastrectomy (LPG). A common feature of the three surgical methods is that the vagus nerve were more or less cut during the operation. Therefore, we plan to further collect gastric cancer patients undergoing endoscopic submucosal dissection (ESD) surgery in order to answer whether the vagus nerve cut during surgery will increase the incidence of gallstones.

Study Type

OBSERVATIONAL

Enrollment

1,019

Conditions

Gallstones Gastric Cancer

Interventions

ResectionPROCEDURE

Radical resection.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Gastric cancer patients * Age from over 18 to under 75 years Exclusion Criteria: * Gallbladder disease before surgery * Gallbladder has been remove * History of previous upper abdominal surgery * History of previous gastrectomy, endoscopic mucosal resection or endoscopic submucosal dissection * History of other malignant disease within past five years * History of previous neoadjuvant chemotherapy or radiotherapy * History of unstable angina or myocardial infarction within past six months * History of cerebrovascular accident within past six months * Requirement of simultaneous surgery for other disease * Emergency surgery due to complication (bleeding, obstruction or perforation) caused by gastric cancer * Pregnant women or breastfeeding * Unwillingness or inability to consent for the study * Severe mental disorder * Unstable vital signs Coagulation dysfunction (INR\>1.5) * Low peripheral blood platelet count (\<50×10 \^9 / L) or using anti- coagulation drugs

Locations (2)

Hepatopancreatobiliary Surgery Institute of Gansu Province

Lanzhou, Gansu, China

Wuwei turmour hospital

Wuwei, Gansu, China

Outcomes

Primary Outcomes

Number of gallstone patients

Four different gastric cancer patients were followed up for more than 1 year. The number of patients with gallbladder stones revealed by B-ultrasound

Time frame: 3 years

Secondary Outcomes

Number of malignant metastasis

Number of malignant metastases after radical gastrectomy in surgery methods of gastric cancer patients

Time frame: 3 years

Number of short-term deaths

Number of short-term deaths after radical gastrectomy in surgery methods of gastric cancer patients

Time frame: 3 months

Number of physical regurgitation, nausea, vomiting, diarrhea, constipation

The number of physical regurgitation, nausea, vomiting, diarrhea, constipation, and other events that affect quality of life in four surgery methods of gastric cancer patients

Time frame: 3 years

Data from ClinicalTrials.gov

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