in Patients With SCAD Undergoing Complex PCI, the RESPONSE Study"

Inclusion Criteria: * Patient must be at least 65 years of age at the time of signing the Informed Consent Form * Patient presenting with SCAD undergoing complex PCI and: * Type 2 Diabetes Mellitus; * CKD (Grade specified in CRF); * Complex SCAD: LMD, 3VD, bifurcation lesions, Rotablator, CTO, multiple Stents, total length of the stents must be greater than 60 mm. * Patient is to be treated for de novo lesions located in previously untreated vessels. * Patient must agree to undergo all required follow-up visits and data collection. Exclusion Criteria: * History of CABG; * In stent restenosis; * Patient with intolerance or contra-indications to treatment with aspirin, clopidogrel, prasugrel, ticagrelor, cangrelor, heparin, contrast media; * Patient on chronic treatment with oral anticoagulants; * Patient with neoplastic or rheumatic diseases; * Use of dipyridamole, cilostazol, or anticoagulant therapy during the study period; * Bleeding disorder * History of an ischemic stroke or intracranial bleeding * Intracranial vascular abnormality; * Gastrointestinal bleeding within the previous 6 months or major surgery within the previous 30 days. * Women who are pregnant/breastfeeding or who have the potential to become pregnant during the study; * Patient with bleeding diathesis in whom antiplatelet drug is contraindicated; * Concomitant indication to open heart surgery * Inability to provide written informed consent * Enrolment in another study within 1 month