Light at Night Study

University of Michigan2 enrolled

Overview

The purpose of this mechanistic study is to examine light sensitivity (melatonin suppression) in people with bipolar depression I, and compare it to healthy controls. This is not a treatment study.

The bipolar disorder I and healthy control arms are recruited from the existing Heinz C. Prechter Bipolar Research Program at the University of Michigan.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Bipolar Disorder Light Sensitivity

Interventions

Light intensity, ~30 luxOTHER

\~30 lux compared to very dim light baseline condition \<1 lux

Baseline light intensity, <1 luxOTHER

Very dim light condition

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI 18-30 kg/m2 * Appropriate sleep schedules according to study staff. Sleep schedule is self-reported and confirmed through a sleep diary * Healthy eyes as ascertained by eye exam at University of Michigan Kellogg Eye Center * Willing and able to maintain stable sleep schedule during study. * Participants will be breathalyzed and undergo urine drugs screens at every lab visit * Acknowledge and understand that participants cannot drive themselves home after certain lab visits. Note that the research team will provide a travel stipend of $10 per visit to offset potential rideshare/taxi costs Exclusion Criteria: * Color blindness

Locations (1)

University of Michigan

Ann Arbor, Michigan, United States

Outcomes

Primary Outcomes

Melatonin levels

Melatonin will be reported as an average percentage of suppression in the \~30 lux condition as compared to \<1 lux

Time frame: Up to approximately 6 weeks

Data from ClinicalTrials.gov

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