The Effect of Intravenous Mannitol Plus Saline on the Prevention of Cisplatin-induced Nephrotoxicity: A Randomized, Double-blind, Placebo Controlled Trial

Inclusion Criteria: 1. Patients who was at least 18 years old. 2. Patients who had been diagnosed with cancer proven by tissue biopsy. 3. Patients who were scheduled to receive cisplatin or combination of cisplatin and other chemotherapy, which the dose of cisplatin was not exceeded 100 mg/m2. 4. Patients were required to have a normal renal function (GFR \> 60 mL/min/1.73m2). 5. Patients with an Eastern Cooperative Oncology Group (ECOG) score ≤ 2. 6. Patients with normal serum sodium and serum potassium level. Exclusion Criteria: 1. Patients with any acute kidney injury event before randomized into trial not more than 6 months. 2. Patients with chronic kidney disease or hydronephrosis. 3. Patients with history of nephrectomy. 4. Patients who had previously received immunosuppressants for any immune deficiency disease. 5. Patients with who had received chemotherapy which induce nephrotoxicity. 6. Patients with had received drug which is nephrotoxic (amphotericin B, aminoglycoside or non-steroidal anti-inflammatory drug). 7. Patients who had cirrhosis with child pugh score more than 7. 8. Patients with or had a known allergy to cisplatin or mannitol. 9. Patients with chronic heart failure who cannot received fluid more than 1 liter. 10. Patients who were not comfortable to follow up at clinic for long term outcome.