Recent human studies found tissue sodium storage in patients with hyperaldosteronism that could be detected non-invasively by 23Na-MRI. Tissue sodium accumulation could be mobilized upon treatment of hyperaldosteronism. Besides, former animal studies applying chemical electrolyte analysis indicate that this aldosterone induced sodium storage might be accompanied by intracellular potassium loss. Wether such an intracellular tissue potassium loss occurs in vivo in patients with hyperaldosteronism and if this deficiency can be corrected by treatment is unclear. The investigators will employ 39K-MR Imaging at 7Tesla to further assess this hypothesis.
Patients diagnosed with primary hyperaldosteronism (PA) will be prospetively investigated using 23Na-MRI and 39K-MRI at 7 Tesla to assess tissue sodium and potassium content (prospective observational study). Measurements will be conducted before treatment of hyperaldosteronism and three to four months after adrenal surgery or medical treatment (Spironolactone or Eplerenone). Furthermore, blood pressure, body water distribution (by bioimpedance spectroscopy), pulse wave velocity and serum electrolytes will be assessed. Additionally, we will conduct a case-control study and compare PA patients before treatment with age- and gender matched healthy control participants. In this study group 23Na-MRI and 39K-MRI at 7 Tesla will be conducted to assess tissue sodium and potassium content using the same MRI protocols as in PA patients. Blood pressure, body water distribution (by bioimpedance spectroscopy), pulse wave velocity and serum electrolytes will be also examined.
Study Type
OBSERVATIONAL
Enrollment
21
Surgery of an unilateral adrenal disease
Treatment of Primary Aldosteronism with Spironolactone or Eplerenone.
Nephrology Department, University Hospital Erlangen
Erlangen, Bavaria, Germany
Radiology Department, University Hospital Erlangen
Erlangen, Bavaria, Germany
Tissue potassium content
1. Change in tissue potassium content measured by MRI before and after treatment of Primary Aldosteronism 2. Difference in tissue potassium content between patients with Primary Aldosteronism before treatment and healthy control subjects
Time frame: 3-6 months after intervention
Tissue sodium content
1. Change in tissue sodium content measured by MRI before and after treatment of Primary Aldosteronism 2. Difference in tissue sodium content between patients with Primary Aldosteronism before treatment and healthy control subjects
Time frame: 3-6 months after intervention
Blood pressure
Change in blood pressure (systolic/diastolic/mean) before and after treatment of Primary Aldosteronism
Time frame: 3-6 months after intervention
Water balance
1. Change in water distribution (intra-/extracellular water, total water, overhydration) assessed by bioimpedance spectroscopy before and after treatment of Primary Aldosteronism 2. Difference in water distribution (intra-/extracellular water, total water, overhydration) assessed by bioimpedance spectroscopy between patients with Primary Aldosteronism before treatment and healthy control subjects
Time frame: 3 - 6 months after intervention
Pulse wave velocity
1. Change in pulse wave velocity measured by SphygmoCor before and after treatment of Primary Aldosteronism 2. Difference in pulse wave velocity between patients with Primary Aldosteronism before treatment and healthy control subjects
Time frame: 3 - 6 months after intervention
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