This prospective study will research the exposure and its variability to fluconazole after longitudinal administration in critically ill patients
An open label, monocenter pharmacokinetic study will be carried out in critically ill patients, admitted at the University Hospitals Leuven, receiving multiple dose treatment with fluconazole. The exposure to fluconazole in the ICU cohort over multiple days of treatment will be documented. Moreover, variability and the correlating covariates that can influence the fluconazole concentration, will be determined.
Study Type
OBSERVATIONAL
Enrollment
43
Plasma and urine sample collection
UZ Leuven
Leuven, Belgium
Exposure to fluconazole (trough levels)
To document the trough levels (Cmin) of fluconazole in an ICU cohort over multiple days of treatment
Time frame: On the day of sampling
Exposure to fluconazole (trough levels)
Determine if the Cmin target levels are attained.
Time frame: June 2020
Variability in fluconazole trough levels
To determine the intra-and intersubject variability of the fluconazole trough levels
Time frame: June 2020
Influencing covariates
Determine possible covariates that might explain the fluconazole variability
Time frame: June 2020
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