The Impact of Gut Microbiota in Anastomoses Insufficiency After Resection and Direct Anastomosis for Colorectal Cancer.

Uppsala University Hospital45 enrolled

Overview

The role of gut microbiota in anastomosis insufficiency in patients operated for colorectal cancer and for peritoneal carcinomatosis is going to be investigated. This is a pilot study.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Colorectal Cancer, Peritoneal Carcinomatosis, Anastomosis Insufficiency

Interventions

Colectomy, CRS+HIPECPROCEDURE

No special interventions are going to be performed. Fecal samples are going to be taken and analysed

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria Colorectal group * adenocarcinom in colon or rektum * curative operation planed * direct anastomose plan * elective surgery Inclusion Criteria HIPEC group : * All patients with appendix, colon or rectal cancer accepted for CRS+HIPEC Exclusion Criteria: * Ongoing antibiotics treatment * antibiotics treatment in the last 6 months * acute surgery * palliative surgery * Ulcerös colitis or Crohns disease * Prior colectomy * Small intestine stoma before the operation * neoadjuvant treatment * Colon preparation

Locations (1)

Uppsala University Hospital

Uppsala, Sweden

Outcomes

Primary Outcomes

Microbiome

Change in microbiome in case of insufficiency of the anastomosis

Time frame: 30 days

Data from ClinicalTrials.gov

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