'MInimalist' or 'MOre Complete' Strategies for Revascularization in Octogenarians

Inclusion Criteria: * Age ≥80 years * Non-ST-elevation acute coronary syndromes, defined as per guidelines: * Ischaemic chest pain or equivalent AND either * Electrocardiography with persistent or transient ST-depression and/or T-wave inversion OR * Biomarker positive for myocardial necrosis * Multi-vessel coronary artery disease, defined as the presence of an angiographic \>90% diameter or FFR-(\<0.81) or iFR-(\<0.90) positive stenoses(29) in a non-culprit vessel of reference diameter ≥2.5mm. Exclusion Criteria: * Inability to give written informed consent * Resuscitation from cardiac arrest * Life expectancy \<12 months * Cardiogenic shock * Ventricular arrhythmias refractory to treatment at the time of randomization * Coronary artery disease not amenable to PCI * Heart Team decision for coronary bypass surgery * Type 2 myocardial infarction(30) or alternative diagnoses such as tako-tsubo cardiomyopathy, as defined by the operator in light of the clinical picture at presentation * Estimated glomerular filtration rate (eGFR) \<20mL/min/m2 (by Cockcroft-Gault formula) * Documented anaphylaxis induced by iodinated contrast media * Documented allergies to either aspirin, clopidogrel, ticagrelor or oral anticoagulants * Any condition that, in the opinion of the investigator, contraindicates anticoagulant therapy or would have an unacceptable risk of bleeding, such as, but not limited to, the following: * Active internal bleeding * Bleeding diastheses precluding treatment with dual antiplatelet therapy and/or oral anticoagulation * Platelet count \<90,000/μL at screening * Previous intracranial haemorrhage * Clinically significant gastrointestinal bleeding within 12 months before randomization * Known significant liver disease (e.g. acute hepatitis, chronic active hepatitis, cirrhosis), or liver function test (LFT) abnormalities at screening (confirmed with repeat testing): alanine transaminase (ALT) \>5 times the upper limit of normal or ALT \>3 times the upper limit of normal plus total bilirubin \>2 times the upper limit of normal * Major surgery, biopsy of a parenchymal organ, or serious trauma (including head trauma) within the past 30 days * Any active non-cutaneous malignancy