Debate on Progesterone Elevation on the Day of Triggering

Istituto Clinico Humanitas8,000 enrolled

Overview

The association between serum progesterone (P) levels, measured on the day of ovulation trigger, and the outcome of in vitro fertilization cycles, has been one of the major controversies in the field of ovarian stimulation endocrinology. This is a single-center retrospective cohort study. Study duration period is from January 2012 to December 2016. All fresh embryo transfer (ET) both at cleavage stage and blastocyst stage, performed in Humanitas Fertility Center during the study period, were included.

Study Type

OBSERVATIONAL

Enrollment

8,000

Conditions

Progesterone ART Female Infertility Embryo Transfer

Interventions

embryo transfer

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All fresh embryo transfers both at cleavage stage (Day 2 and Day3) and blastocyst stage (Day 5) * Thawed embryo transfer deriving from supernumerary embryos cycles, by P increase, by OHSS, by other reasons (i.e inadequate endometrium, medical complications, etc) Exclusion Criteria: * thawed embryo transfers deriving from PGTA.

Outcomes

Primary Outcomes

Impact of PE on CPR and LBR

To evaluate the impact of premature high serum P levels on the outcome of fresh embryo transfer cycles in terms of Clinical Pregnancy Rates (CPR) and Live Birth Rates (LBR).

Time frame: January 2012-December 2016

Secondary Outcomes

Blastocyst embryo transfers' outcomes in PE

Furthermore, the present study retrospectively investigates whether the transfer of blastocysts on day 5 post-fertilization (D5-ET) may improve the CPR and the LBR in patients with P rise.