Risk of Recurrence of Cervical Artery Dissection During Pregnancy and Puerperium

Nantes University Hospital91 enrolled

Overview

Cervical artery dissection (CAD) accounts for about 2% of all strokes, and is a major cause of stroke in young people (about 15%). Many cases of CAD during pregnancy and puerperium have been described, suggesting that pregnancy and puerperium may be potential risk factors for CAD. The purpose of this study is to determine whether pregnancy and puerperium are also recurrence risk factors for CAD.

In this study, all women of childbearing age who had had a CAD between 2005 and 2017 are selected. Women are identified using the ICD10 diagnostic coding system. In addition, a text search with key words ("cervical or carotid or vertebral dissection") has been created in a data warehouse of the University Hospital of Nantes. To determine the recurrence of CAD during pregnancy and puerperium, the participating women will be asked to answer to a questionnaire, by phone or mail. The questionnaire will be conducted by the same investigator, an experienced neurologist. Information about recurrence of CAD, number of pregnancies before and after the event will be recorded, as well as, the site of obstetrical monitoring, way of delivery, and management of antithrombotics, in case of further pregnancy. In case of no further pregnancy after the dissection, the reason will be explored.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cervical Artery Dissection

Interventions

questionnariesOTHER

Study on questionnaries

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Extracranial carotid or vertebral dissection * Symptomatic dissection (with symptom onset within the last four weeks) * Spontaneous dissection * Imaging evidence of dissection on MRI/MRA, CTA or ultrasound. Exclusion Criteria: * Minors or adults under guardianship * Intracranial artery dissection * Traumatic or iatrogenic dissection * Patient refusal to participate

Locations (1)

University Hospital

Nantes, France

Outcomes

Primary Outcomes

Recurrence of CAD during pregnancy, childbirth or puerperium

This primary study endpoint will be evaluated by a questionnaire asked directly to participating women.

Time frame: Day 0

Secondary Outcomes

To determine the absolute risk of recurrence of CAD in this population.

This secondary endpoint will be evaluated by a questionnaire asked directly to participating women.

Time frame: Day 0

To assess obstetrical monitoring, way of delivery, and management of antithrombotics during further pregnancy.

This secondary endpoint will be evaluated by a questionnaire asked directly to participating women.

Time frame: Day 0

To study the reasons of absence of pregnancy after a history of CAD

This secondary endpoint will be evaluated by a questionnaire asked directly to participating women.

Time frame: Day 0

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.