This study is to evaluate the safety and efficacy of 60mg ticagrelor plus 100mg Aspirin to prevent major adverse cardiovascular and cerebrovascular events in one years after drug-eluting stents implantation for Chinese ACS patients compared with 90mg ticagrelor plus 100mg Aspirin
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
2,120
Ticagrelor 60mg plus Aspirin 100mg for experimental group
Ticagrelor 90mg plus Aspirin 100mg for active comparator group
Taishan people's hospital
Taishan, Guangdong, China
RECRUITINGSouth East of Shandong hospital
Liaocheng, Shandong, China
RECRUITINGzhangshan hospital, Fudan University
a composite of cardiovascular death, non-fatal myocardial infarction, stent thrombosis,coronary revascularization,stroke, and bleeding events of BARC grade ≥2
a composite of death from coronary vascular causes,non-fatal myocardial infarction,stent thrombosis,coronary revascularization, stroke and bleeding type 2, 3 or 5 according to the Bleeding Academic Research Consortium (BARC) criteria
Time frame: Stent implantation to 12 months
bleeding events of BARC grade ≥2
bleeding type 2, 3 or 5 according to the Bleeding Academic Research Consortium (BARC) criteria
Time frame: Stent implantation to 12 months
a composite of cardiovascular death, non-fatal myocardial infarction, stent thrombosis,coronary revascularization,stroke
a composite of cardiovascular death, non-fatal myocardial infarction, stent thrombosis,coronary revascularization,stroke
Time frame: Stent implantation to 12 months
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Shanghai, Shanghai Municipality, China
shanghai Tongren hospital
Shanghai, Shanghai Municipality, China
RECRUITINGMinhang hospital, Fudan University
Shanghai, Shanghai Municipality, China
NOT_YET_RECRUITINGSongjiang hospital, Shanghai jiaotong university, school of medicine
Shanghai, Shanghai Municipality, China
NOT_YET_RECRUITINGNingbo 4th hospital
Xiangshan, Zhejiang, China
RECRUITINGYanzhou branch of affiliated hospital of Jining medical university
Jining, China
NOT_YET_RECRUITING