Efficacy of a Multi-faceted Intervention to Deprescribe Proton Pump Inhibitors (PPI) in Primary Care: a Population-based, Pragmatic, Cluster-randomized Controlled Trial.

Inclusion Criteria: * General practitioners (GPs): • All GPs settled in the 2 departments of Loire-Atlantique and Vendée with more than 100 patients in the year before baseline, will be eligible. * Patients: * aged over 18 years * affiliated to the French health insurance system (CPAM) * treated with PPI with more than 300 DDD/year in the year before baseline, estimated with reimbursement databases. * whose GP is included in the study Exclusion Criteria: * General practitioners (GPs): • Participation refusal * Patients : * Participation refusal * Patients at risk of gastroduodenal lesions i.e. treated with nonsteroidal anti-inflammatory drugs (NSAIDs) and over 65 years old or treated with either corticosteroids or anticoagulants or platelet aggregation inhibitors