Water Load Test Value for Hyponatremia

European Georges Pompidou Hospital150 enrolled

Overview

Acute water load test has been using to diagnose renal ability to excrete water for decades. Latest recommendations for the diagnosis of hyponatremia do not recommend performing such a test. The investigators aim at, retrospectively, study the value of acute water load test in patients suffering from a syndrome of inappropriate antidiuresis.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

SIAD - Syndrome of Inappropriate Antidiuresis Hyponatremia

Interventions

Acute water load testPROCEDURE

The acute water load test consists in administering orally 20 mL/kg (of body weight) of water (ingested in less than 30 min) and then follow (during 4 to 6 hours) blood and urine parameters.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ≥ 18 years old at the time of the test * affiliated to a social insurance system * water load test performed at the Renal and Metabolic Diseases Unit of the European George Pompidou Hospital, AP-HP, Paris, France * between 01/01/2001 and 12/31/2019 Exclusion Criteria: * hypernatremia and/or polyuria-polydipsia (diabetes insipidus) * hyponatremia due to a tea and toast syndrome and/or a beer potomania * hyponatremia due to a high (or normal) osmolality related to diabetes mellitus, hyperproteinemia and/or intoxication * chronic kidney disease with an estimated glomerular filtration rate (eGFR) by the MDRD formula \<60 mL/min/1.73m2 * hyponatremia related to thiazides * hyponatremia related to an hypovolemic status * syndrome of inappropriate antidiuresis related to an endocrine disorder (such as hypothyroidism or adrenal insufficiency)

Locations (1)

European Georges Pompidou Hospital, APHP

Paris, France

Outcomes

Primary Outcomes

Natremia

Plasma sodium concentration (abnormal if \<135mM)

Time frame: any time after water load test from hour 2 to hour 6

Secondary Outcomes

Plasma osmolality

Plasma osmolality (abnormal if \<280mOsm/kgH2O)

Time frame: any time after water load test from hour 2 to hour 6

Excretion of water load

Ratio between the excreted water (in urine) volume and the ingested one

Time frame: after water load test from hour 0 to hour 6

Urine osmolality

Minimum urine osmolality reached

Time frame: any time after water load test from hour 2 to hour 6

Data from ClinicalTrials.gov

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