Severe ischemic changes of the liver remnant after hepatectomy could expedite tumor recurrence on the residual liver. Our study aimed at assessing the effect of warm ischemic/reperfusion (I/R) injuries on surgery-to-local recurrence interval and patient overall survival, during major hepatectomies under inflow and outflow vascular control.
One hundred and eighteen patients were subjected to liver resection under total inflow and outflow vascular clamping and were assigned as study group. These individuals were retrospectively matched to 112 counterparts, who underwent liver surgery applying inflow and outflow vascular clamping only of the segment harboring the tumor, sparing the liver remnant from any I/R injury (control group). The two cohorts were compared regarding recurrence-free survival and overall survival.
Study Type
OBSERVATIONAL
Enrollment
230
major hepatectomy with vascular control of blood inflow and outflow of the whole liver
major liver resection by selectively clamping the portal and hepatic vessels only of the lobe harboring the tumor
time to malignant recurrence
recurrence-free survival
Time frame: from time of operation until time of malignant recurrence, assessed up to 15 years
time to death
overall survival
Time frame: from time of operation until time of death, assessed up to 20 years
aspartate aminotrasferase (AST) levels
aspartate aminotransferase levels
Time frame: second postoperative day
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