Qualitative and Quantitative Evaluation of Vascular Flows of Radial, Ulnar and Interdigital Arterial Trees Under Normal and Pathological Conditions by 3 Tesla MRI

Centre Hospitalier Universitaire, Amiens46 enrolled

Overview

Allotransplants of vascularized composite tissues are subject to chronic vascular rejection, which can lead to graft loss. Currently, no imaging technique allows a reproducible quantitative exploration of the arterial trees of the hand, and therefore a satisfactory monitoring of transplants. Since 2014, flow MRI has been applied to the analysis of small-calibre arteries by the Image Processing Team at the Amiens-Picardie University Hospital. Between 2015 and 2017, several acquisitions were made in 3 patients who received facial allotransplantation, and the team recently developed a flow MRI protocol dedicated to the study of arterial trees in the hand. The main objective is to measure vascular flows of radial, ulnar and interdigital arterial trees in normal (healthy volunteers) and pathological situations (patients with radial forearm flap reconstruction and patients with hand allotransplantation) using the specifically developed flow MRI protocol.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Magnetic Resonance Imaging Vascular Complications Transplantation

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adult (≥ 18 years old) * patients who has received appropriate information and provided informed consent * patients benefiting from social security insurance * patients with no contraindications to magnetic resonance imaging * healthy volunteer or patient requiring radial forearm flap reconstruction or having received hand allotransplantation. Exclusion Criteria: * Person with a contraindication to MRI * pregnant or breastfeeding woman * minors (\< 18 years) * person under guardianship or deprived of liberty by a judicial or administrative decision * person with upper limb arteriopathy with the exception of the hand transplant patients group.

Outcomes

Primary Outcomes

Variation of radial vascular flows between healthy volunteers and patients with forearm flap reconstruction

Radial vascular flows between healthy volunteers and patients with forearm flap reconstruction will be determined by using the specifically developed flow MRI protocol

Time frame: day 0

Variation of ulnar artery vascular flows between healthy volunteers and patients with forearm flap reconstruction

Ulnar artery vascular flows between healthy volunteers and patients with forearm flap reconstruction will be determined by using the specifically developed flow MRI protocol

Time frame: day 0

Variation of interdigital arterial tree vascular flows between healthy volunteers and patients with forearm flap reconstruction

Interdigital arterial tree vascular flows between healthy volunteers and patients with forearm flap reconstruction will be determined by using the specifically developed flow MRI protocol

Time frame: day 0

Variation of radial vascular flows between healthy volunteers and patients with hand allotransplantation

Radial vascular flows between healthy volunteers and patients with hand allotransplantation will be determined by using the specifically developed flow MRI protocol

Time frame: day 0

Variation of ulnar artery vascular flows between healthy volunteers and patients with hand allotransplantation

Ulnar artery vascular flows between healthy volunteers and patients with hand allotransplantation will be determined by using the specifically developed flow MRI protocol

Time frame: day 0

Variation of interdigital arterial tree vascular flows between healthy volunteers and patients with hand allotransplantation

Interdigital arterial tree vascular flows between healthy volunteers and patients with hand allotransplantation will be determined by using the specifically developed flow MRI protocol

Time frame: day 0

Qualitative and Quantitative Evaluation of Vascular Flows of Radial, Ulnar and Interdigital Arterial Trees Under Normal and Pathological Conditions by 3 Tesla MRI

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts