Quercetin for Cardio-Skeletal Muscle Health and Estrogen Deficiency

Inclusion Criteria: * Female, postmenopausal, aged 60 to 74 * Stated willingness to comply with all study procedures and availability for the duration of the study * High risk of Heart failure with preserved ejection fraction (HFPEF) using web-based Primary Care Physician-HF risk tool (Khan S, et al.10-Year Risk Equations for Incident Heart Failure in the General Population. Information used for calculation include: age, gender, race, hypertension treatment (yes or no), fasting glucose value, smoking status, body mass index, systolic BP, diabetes treatment (yes or no), total cholesterol, HDL cholesterol, and electrocardiogram QRS duration. Prospective participant's with scores \>= 10% will be included. * Electrocardiogram (EKG) on medical record Exclusion Criteria: * History of congestive heart failure or use of loop diuretics * Recent myocardial infarction (MI), stroke, angina, or atrial fibrillation (in the past 6 months), either self-reported and or in the electronic medical record. * Uncontrolled diabetes mellitus * Uncontrolled hypertension * Significant renal insufficiency requiring dialysis or estimated glomerular filtration rate (eGFR) \< 15 mL/min * Liver disease * Psychiatric disease - uncontrolled major psychoses, depressions, dementia, or personality disorder * Participants reporting extreme energy intakes \>3500 or \<500 kcal/day * Plans to leave area within the study period * Refuses informed consent