The aim of this research is to evaluate thiol-disulfide balance in cervix cancer patients
To date various oxidative stress parameters were studied in patients with cervix cancer, however dynamic thiol disulfide hemostasis has not been previously investigated. The thiol-disulfide balance in the circulation will be measured by the automated system created by Erel \& Neselioglu (1). References 1- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32. doi:10.1016/j.clinbiochem.2014.09.026.
Study Type
OBSERVATIONAL
Enrollment
123
Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with spectrophotometry
Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with spectrophotometry
The serum Ischemia Modified Albumin concentrations were measured as described by Bar-Or et al. (Bar-Or et al. 2000).
Mugla Sıtkı Kocman University Faculty of Medicine
Muğla, Turkey (Türkiye)
serum native thiol level
serum native thiol level in μmol/L
Time frame: preoperative in the morning or preprandial for healthy volunteers
serum disulphide level
serum disulphide level in μmol/L
Time frame: preoperative in the morning or preprandial for healthy volunteers
serum total thiol level
serum total thiol level in μmol/L
Time frame: preoperative in the morning or preprandial for healthy volunteers
the disulphide/native thiol ratio
the disulphide/native thiol ratio X (100 )
Time frame: preoperative in the morning or preprandial for healthy volunteers
disulphide/total thiol ratio
disulphide/total thiol ratio X (100 )
Time frame: preoperative in the morning or preprandial for healthy volunteers
native thiol/total thiol ratio
native thiol/total thiol ratio X (100 )
Time frame: preoperative in the morning or preprandial for healthy volunteers
total oxidant capacity (TOC)
TOC in mmol H2O2 equivalent/L
Time frame: preoperative in the morning or preprandial for healthy volunteers
total antioxidant capacity (TAC)
TAC in mmol trolox equivalent/L
Time frame: preoperative in the morning or preprandial for healthy volunteers
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Oxidative stress index (OSI)
OSI in mmol trolox/L.
Time frame: preoperative in the morning or preprandial for healthy volunteers
ischaemia-modified albumin
ischaemia-modified albumin in IU/mL
Time frame: preoperative in the morning or preprandial for healthy volunteers