Neoadjuvant Chomotherapy With Paclitaxel-albumin and S-1 for Advanced Gastric Cancer

Inclusion Criteria: 1. pathologically diagnosed gastric adenocarcinoma 2. Type II and III esophageal-gastric-junction malignancy 3. AJCC stage II-III 4. No contraindications for surgery, radical resection can be expected 5. KPS\>60; ECOG score:0-2 6. Expactant survival period\>6 months 7. Age 20\~75 8. No other major health issues 9. Lab results within 7 days before inclusion must satisfy: 1. neutrophil≥1.5×109/L 2. PLT≥100×109/L 3. hemogloblin≥90g/L 4. ALT,AST\<1.5 upper limit 5. Tbil≤1.0×UNL 6. serum creatinine\<1.5×UNL 7. PT-INR/PTT\<1.7 upper limit 10. with measurable lesion according to RECIST1.1 criteria 11. with consent 12. co-operative Exclusion Criteria: 1. with other major health issue 2. allergic to relevant drugs 3. experienced any other drug therapy with 4 weeks before inclusion 4. experienced any drug therapy for gastric cancer at anytime 5. diagnosed with any other malignancy within the past 5 years 6. women at child-bearing age; pregnant or breast-feeding women 7. with severe heart disease 8. with upper GI digestion or disrupted absorption 9. with peripheral neural disease 10. with transplated organs or organs having been resected for transplantation 11. known DPD deficiency 12. with uncontrolled infection