This study investigates the influence of type of anesthesia on survival and recurrence rate in patients receiving colon cancer surgery. The participants will be allocated to either the TIVA group and the inhalation group.
The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, total intravenous anesthesia (TIVA) is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, there is no randomized controlled study to determine this difference in colon cancer patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
797
propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia
sevoflurane is administered for induction and maintenance of anesthesia
Seoul Metropolitan Government Seoul National University Boramae Medical Center
Seoul, South Korea
Seoul National University Hospital
Seoul, South Korea
five year survival
survival rate regardless of recurrence
Time frame: five years survival
five year recurrence free survival
survival rate without recurrence
Time frame: five years after surgery
1 year recurrence free survival
survival rate without recurrence
Time frame: 1 year after surgery
3 year recurrence free survival
survival rate without recurrence
Time frame: 3 years after surgery
1 year survival
survival regardless of recurrence
Time frame: 1 year after surgery
3 year survival
survival regardless of recurrence
Time frame: 3 years after surgery
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