The anastomotic and peripheral stenosis of the transplanted kidney artery is one of the most important causes of graft failure in renal transplantation. The injury of vascular intima and the formation of microthrombosis may play a significant role in the stenosis of transplanted renal artery of recipients. Inhibiting this process with aspirin may protects against the stenosis of transplanted renal artery. This is a prospective, randomized, controlled, clinical trial to investigate the efficacy and safety of prevention of renal artery stenosis in recipients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
368
Daily active drug administered orally for 3 months.
Sugar pill administered orally for 3 months.
Henan Provincial People's Hospital
Zhengzhou, Henan, China
RECRUITINGIncidence of Renal Artery Stenosis
Renal artery stenosis is defined as the presence of post-transplant renal artery stenosis in recipients evaluated by ultrasonography or renal arteriography.
Time frame: 2 years
Renal Allograft Function
Renal allograft function is evaluated by mean estimated glomerular filtration rate(eGFR).
Time frame: 2 years
Incidence of Graft Loss
The incidence of kidney failure within 2 years of transplant.
Time frame: 2 years
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