Drug-drug-interaction Study of Ramipril, Amlodipine and Atorvastatin

Inclusion Criteria: * Male Caucasian, aged 18 to 50 years, inclusive. * Body Mass Index (BMI) range within 18.5 - 30.0 Kg/m2. * Physically and mentally healthy as judged by means of medical and standard laboratory examinations. Medical demographics performed not longer than two weeks before the initiation of the clinical study with significant deviations from the normal ranges. * Standard ECG assessment is normal * Informed consent given in written form according to chapter 5.3 of the study protocol. Exclusion Criteria: * Known allergy to the drugs under investigation or any ingredients or any other related drugs. * Participation in a relative bioavailability study or in a clinical study within the last 80 days before first study drug administration or blood donation * Presence of any clinically significant results from laboratory tests, vital sign assessment and electrocardiogram as judged by the investigator. Laboratory tests are performed not longer than two weeks before the initiation of the clinical study. * Results of CPK or liver or kidney function tests which are outside the reference range. * Hb test lower than 13.3 g/dl. * Positive serologic findings * History of drug or alcohol abuse. * Subject is a heavy smoker. * Subject has a history of significant asthma, peptic or gastric ulcer, sinusitis, pharyngitis, renal disorder (impaired renal function), hepatic disorder (impaired hepatic function), cardiovascular disorder, neurological disease such as epilepsy, haematological disorders or diabetes, psychiatric, dermatologic or immunological disorders. * Subject having at screening examination a sitting blood pressure of less than 110/70 mm Hg or more than or equal to 140/90 mm Hg. * Subjects who are known or suspected: not to comply with the study directives, not to be reliable or trustworthy, not to be capable of understanding and evaluating the information given to them as part of the formal information policy (informed consent), in particular regarding the risks and discomfort to which they would agree to be exposed, to be in such a precarious financial situation that they no longer weigh up the possible risks of their participation and the unpleasantness they may be involved in.