We evaluated here the effects of 6-week intervention with herbal supplement on exercise performance outcomes and serum biomarkers of antioxidant status. In addition, we also assessed the long-term effects (6-month) of the intervention in elderly adults.
Experimental protocol * Double-blind, randomized, placebo-controlled cross-over trial * 6-week intervention trial (with additiional follow-up arm after 6 months) * Experimental intervention (PhytoDyNAmic) = 6 capsules per day * Placebo (inulin) = 1 g per day b.i.d. * Administration = 3 capsules with breakfast and 3 capsules with dinner * Wash-out period = 2 weeks * No changes in physical activity patterns and diet during the study Outcomes assessed at baseline and at each follow-up: * Exercise performance during incremental running-to-exhaustion test * Serum biomarkers of antioxidant status * Total antioxidant capacity (TAC) * Superoxide dismutase (SOD) * Telomerase activity Early termination criteria \- Serious subjective side effects of an intervention (e.g. nausea, vomiting, bloating)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
12
PhytoDyNAmic (6 capsules per day)
Inulin (6 capsules per day)
Applied Bioenergetics Lab at Faculty of Sport and PE
Novi Sad, Vojvodina, Serbia
Change in time to exhaustion
Baseline vs. 6 weeks
Time frame: Baseline vs. 6 weeks post-intervention
Change in serum superoxide dismutase
Baseline vs. 6 weeks
Time frame: Baseline vs. 6 weeks post-intervention
Change in serum total antioxidant capacity
Baseline vs. 6 weeks
Time frame: Baseline vs. 6 weeks post-intervention
Change in serum telomerase activity
Baseline vs. 6 weeks
Time frame: Baseline vs. 6 weeks post-intervention
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